Vinculin in cell–cell and cell–matrix adhesions
Top Cited Papers
Open Access
- 11 April 2017
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 74 (16), 2999-3009
- https://doi.org/10.1007/s00018-017-2511-3
Abstract
Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell–cell and cell–matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. We also highlight the recent understanding of how vinculin responds to and transmits force at integrin- and cadherin-containing adhesion complexes to the cytoskeleton. Furthermore, we discuss roles of vinculin in binding to and rearranging the actin cytoskeleton.Keywords
Funding Information
- The National Institutes of General Medicine (R01GM112805)
- National Cancer Institute of the National Institutes of Health (P30CA086862)
- American Heart Association (AHA16PRE26701111)
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