Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016
Open Access
- 15 September 2017
- journal article
- clinical trial
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 12 (9), e0185048
- https://doi.org/10.1371/journal.pone.0185048
Abstract
From April to November 2016, two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively at primary and middle schools in the Tibet Autonomous Region of China, and a total of 197 clinically diagnosed cases were reported. Real-time PCR analyses confirmed that human adenovirus (HAdV) infection was related to these outbreaks. Further studies involving sequence determination and phylogenetic analysis based on the penton base, hexon, and fiber genes indicated that human adenovirus type 8 (HAdV-8), belonging to species D, was responsible for the outbreaks. This is the first report of a HAdV-8 associated EKC outbreak in mainland of China, and the results of this study are expected to provide support for future research into HAdV-8 in China.Keywords
This publication has 27 references indexed in Scilit:
- Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type 56, China, 2012PLOS ONE, 2014
- Human adenovirus type 8 genome typingJournal of Medical Microbiology, 2012
- MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony MethodsMolecular Biology and Evolution, 2011
- Spread of Epidemic Keratoconjunctivitis Due to a Novel Serotype of Human Adenovirus in JapanJournal of Clinical Microbiology, 2009
- Adenoviruses: update on structure and functionJournal of General Virology, 2009
- Novel Human Adenovirus Causing Nosocomial Epidemic KeratoconjunctivitisJournal of Clinical Microbiology, 2008
- Phylogenetic Analysis of the Main Neutralization and Hemagglutination Determinants of All Human Adenovirus Prototypes as a Basis for Molecular Classification and TaxonomyJournal of Virology, 2005
- Comprehensive Detection and Serotyping of Human Adenoviruses by PCR and SequencingJournal of Clinical Microbiology, 2004
- The change of etiological agents and clinical signs of epidemic viral conjunctivitis over an 18-year period in southern TaiwanAlbrecht von Graefes Archiv für Ophthalmologie, 2003
- A Twenty-One Year Surveillance of Adenoviral Conjunctivitis in Sapporo, JapanInternational Ophthalmology Clinics, 2002