Helicobacter pylori infection and atrophic gastritis
Open Access
- 12 April 2013
- journal article
- Published by African Journals Online (AJOL) in African Health Sciences
- Vol. 13 (1), 112-117-7
- https://doi.org/10.4314/ahs.v13i1.15
Abstract
Background: Helicobacter pylori-infection associated gastritis is known to be a significant risk factor of gastric cancer. Serum levels of Gastrin-17 and Pepsinogen1which are respectively biomarkers of gastric antral and corpus mucosal activity are well known parameters of atrophic gastritis. Objectives: To determine the prevalence of Helicobacter pylori and atrophic gastritis amongst dyspeptic patients and to compare the production of PGI and G-17 in the various atrophic stages. Methods: A total of 139 dyspeptic patients aged 46.68±15.50 years [females 106 aged47.23±15.51years, males 33 aged 44.48±14.62] were included during the one year period, March 2008-april 2009 at the district hospital Tombel. The degree of atrophy was determined by the levels of serum pepsinogen1, and gastrin-17 and the presence of Helicobacter pylori antibodies detected by an enzyme immunoassay. Results: The prevalence of Helicobacter pylori was 79.82% and that for atrophic gastritis was 6.6%. A decrease in mean serum levels of gastin-17 along with increasing antral atrophy was observed; the mean serum levels of pepsinogen1 were reduced during progression of corpus atrophy. Conclusion: A weak reverse correlation(r =-0.036) was found between Gastrin-17 and Helicobacter pylori antibodies. Key words: Helicobacter pylori, atrophic gastritis, gastrin, pepsinogenKeywords
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