Clinical Features and Survival of Pregnancy-Associated Breast Cancer: A Retrospective Study of 203 Cases in China
Open Access
- 12 March 2020
- preprint content
- Published by Research Square Platform LLC
Abstract
Background: Pregnancy-associated breast cancer (PABC) is an aggressive disease, and sinceChinese authoritybegan to encourage childbearing in 2015, the incidence of PABC has increased. This study investigated the characteristics and survival of PABC patients. Methods: Patients with PABC who underwent surgery at Fudan University, Shanghai Cancer Center between 2005 and 2018 were enrolled.Data concerning the tumor characteristics, maternal state (whether first or non-first pregnancy ) and survival outcome were recorded. Pearson Chi-square tests were used to compare the characteristics of the tumors, and Kaplan-Meier methods were used to perform the survival analysis. Results: Overall, 203 PABC patients were recruited. Since 2015, 65.5% of non-first pregnant women were diagnosed with breast cancer, it’s 5.7 fold of the incidence of PABC in non-first pregnant women. No significant differences in tumor characteristics were observed between the patients who were in their first pregnancy and those in non-first pregnancy. Among the entire PABC population, luminal B breast cancer accounted for the largest proportion (38.4%), followed by triple-negative breast cancer (TNBC, 30.0%). The distribution of the molecular subtypes of PABC and non-PABC differed (P<0.001) as follows: in the PABC patients, Luminal B 38.4%, Triple negative breast cancer (TNBC) 30.1%, Human Epidermal Growth Factor Receptor 2 (HER-2) overexpression 15.8%, and Luminal A 10.8%; in the non-PABC patients, Luminal A 50.9%, Luminal B 20.1%, TNBC 17.4%, and HER-2 overexpression 8.0%. The 3-year disease free survival (DFS) of all PABC patients was 80.3%. The 3-year DFS of the patients in the first-pregnancy group was 78.4%, and that of the patients in the non-first-pregnancy group was 83.7% (P=0.325). Conclusions: Our study proved that the proportion of women who developed PABC during the second or third pregnancy was extremely high relative to the newborn populations. The patients in the PABC population tended to present more luminal B and TNBC breast cancer than the non-PABC patients.Keywords
This publication has 30 references indexed in Scilit:
- Clinical subtypes and prognosis of pregnancy-associated breast cancer: results from the Korean Breast Cancer Society Registry databaseBreast Cancer Research and Treatment, 2018
- Tumor characteristics and prognosis in women with pregnancy-associated breast cancerInternational Journal of Cancer, 2018
- The prognosis of women diagnosed with breast cancer before, during and after pregnancy: a meta-analysisBreast Cancer Research and Treatment, 2016
- Association with pregnancy increases the risk of local recurrence but does not impact overall survival in breast cancer: A case–control study of 87 casesThe Breast, 2015
- Clinicopathological Features and Prognosis of Pregnancy Associated Breast Cancer – A Matched Case Control StudyPathology and Oncology Research, 2013
- Stage at diagnosis and mortality in women with pregnancy-associated breast cancer (PABC)Breast Cancer Research and Treatment, 2013
- Current or recent pregnancy is associated with adverse pathologic features but not impaired survival in early breast cancerCancer, 2011
- The impact of pregnancy on breast cancer outcomes in women ≤35 yearsCancer, 2009
- Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in uteroCancer, 2006
- Pregnancy-associated breast cancer: a case— control study in a young population with a high-fertility rateMedical Oncology, 2000