Composition of Phospholipid Fatty Acids in Red Blood Cell Membranes of Patients in Intensive Care Units: Effects of Different Intakes of Soybean Oil, Medium‐Chain Triglycerides, and Black‐Currant Seed Oil
- 1 March 1992
- journal article
- Published by Wiley in Journal of Parenteral and Enteral Nutrition
- Vol. 16 (2), 136-141
- https://doi.org/10.1177/0148607192016002136
Abstract
Fatty acid composition of phospholipids in red blood cell membranes was studied in 32 severely head-injured or cerebral stroke patients receiving enteral nutrition for 3 weeks. During this study the effects of three diets differing only by their lipid composition were investigated. The daily energy intake of each patient amounted to 2950 kilocalories, of which the lipid fraction represented 45.7%. Diet A contained only soybean oil, diet B consisted of a 50% soybean oil and 50% medium-chain triglycerides mixture, and diet C was an emulsion of 50% soybean oil, 42.5% medium-chain triglycerides, and 7.5% black-currant seed oil. Our results showed no biochemical signs of fatty acid deficiency in red blood cell membranes for the patients at the beginning of the study, after a comparison with a control group of 20 healthy adults. Inhibition of Δ6-desaturase activity on linoleic acid (C18:2ω6) after diet A was suggested by an increase of linoleic acid without a corresponding increase of dihomo-γ-linolenic acid (C20:3ω6). Replacing 50% of soybean oil by with medium-chain triglycerides (diet B) prevented this enzyme inhibition. Supply of black-currant seed oil rich in γ-linolenic (C18:3ω6) and stearidonic (C18:4ω3) acids (diet C) induced significant increases of dihomo-γ-linolenic and eicosapentaenoic (C20:5ω3) acids, without influencing arachidonic acid (C20:4ω6) levels. This balance was evaluated through the ratio (C20:3ω6 + C20:5ω3)/C20:4ω6. (Journal of Parenteral and Enteral Nutrition 16:136-141, 1992)Keywords
This publication has 24 references indexed in Scilit:
- Red blood cell fatty acids in multiple sclerosisActa Neurologica Scandinavica, 1989
- Abnormalities of Plasma and Erythrocyte Essential Fatty Acid Composition in Epidermolysis Bullosa: Influence of Treatment With DiphenylhydantoinJournal of Investigative Dermatology, 1987
- Fatty acids of plasma lipids, red cells and platelets in Alzheimer's disease and vascular dementiaAtherosclerosis, 1987
- Fatty acid pattern of red blood cell membranes and risk of ischemic brain infarction: a case-control study.Stroke, 1987
- Low prevalences of coronary heart disease (CHD), psoriasis, asthma and rheumatoid arthritis in Eskimos: Are they caused by high dietary intake of eicosapentaenoic acid (EPA), a genetic variation of essential fatty acid (EFA) metabolism or a combination of both?Medical Hypotheses, 1987
- A study of the effect of α-linolenic acid on the desaturation of dihomo-γ-linolenic acid using rat liver homogenatesReproduction Nutrition Développement, 1984
- Metabolic Utilization of Intravenous Fat Emulsion During Total Parenteral NutritionAnnals of Surgery, 1982
- Invited Review: Development of Fat EmulsionsJournal of Parenteral and Enteral Nutrition, 1981
- Medium Chain Triglycerides in Parenteral NutritionJournal of Parenteral and Enteral Nutrition, 1981
- Nutritional and hormonal factors influencing desaturation of essential fatty acidsProgress in Lipid Research, 1981