Lipoprotein(a) and Incident Ischemic Stroke
- 1 June 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 37 (6), 1407-1412
- https://doi.org/10.1161/01.str.0000222666.21482.b6
Abstract
Background and Purpose— Numerous case-control and cross-sectional studies have reported higher median lipoprotein(a) [Lp(a)] levels among stroke patients than controls, but existing prospective studies have not consistently shown an association. We sought to examine the relationship between plasma Lp(a) levels and the incidence of ischemic stroke among blacks and whites. Methods— Between 1987 and 1989, 14 221 men and women (3647 blacks and 10 574 whites) aged 45 to 64 years and free of clinical cardiovascular disease, took part in the first examination of the Atherosclerosis Risk in Communities (ARIC) study cohort. Lp(a) and other risk factors for cardiovascular disease were measured at baseline. Results— During the 13.5-year follow-up, 496 ischemic strokes occurred. Participants with Lp(a) ≥300 μg/mL had a 79% higher age, sex, and race-adjusted rate ratio (RR) of ischemic stroke than did those with Lp(a) levels Conclusions— A high Lp(a) concentration is associated with a higher incidence of ischemic stroke in blacks and white women, but not in white men.Keywords
This publication has 12 references indexed in Scilit:
- Lp(a) Lipoprotein, Vascular Disease, and Mortality in the ElderlyThe New England Journal of Medicine, 2003
- Plasma Lipid Profile and Incident Ischemic StrokeStroke, 2003
- Lipoprotein (a) and development of intermittent claudication and major cardiovascular events in men and women: The Edinburgh Artery StudyAtherosclerosis, 2001
- Lipoprotein (a) and strokeJournal of Clinical Pathology, 2000
- Lipoprotein(a) as a correlate of stroke and transient ischemic attack prevalence in a biracial cohort: The ARIC studyAnnals of Epidemiology, 1994
- Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based studyAtherosclerosis, 1994
- Short-term Intraindividual Variability in Lipoprotein Measurements: The Atherosclerosis Risk in Communities (ARIC) StudyAmerican Journal of Epidemiology, 1992
- The Mysteries Of Lipoprotein(a)Science, 1989
- THE ATHEROSCLEROSIS RISK IN COMMUNIT (ARIC) STUDY: DESIGN AND OBJECTIVESAmerican Journal of Epidemiology, 1989
- A comparison of direct adjustment and regression adjustment of epidemiologic measuresJournal of Chronic Diseases, 1985