Absorption and Excretion of Drugs. XXVII. Effect of Nonionic Surface-Active Agents on Rectal Absorption of Sulfonamides
- 1 January 1965
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 13 (8), 976-985
- https://doi.org/10.1248/cpb.13.976
Abstract
The rectal absorption of sulfonamides were re-duced by the addition of various nonionic surface-active agents. This reduction depends upon the entrapment of drug in micelles. The drug in micelles was also absorbed a little, and therefore the enhancement of drug absorption were obtained by solubilization of the drug remained as a solid in solution. The mechanism of drug absorption in the presence of nonionic surface-active agent can be explained by the concept that there are 2 ways of the passage of the free drug and of the drug in micelles.This publication has 5 references indexed in Scilit:
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