Amino Acid Composition of Proteins: Selection Against the Genetic Code
- 4 July 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 189 (4196), 50-51
- https://doi.org/10.1126/science.237322
Abstract
Distribution of amino acids in 68 representative proteins is compared with their distribution among 61 codons of the genetic code. Average amounts of lysine, aspartic acid, glutamic acid, and alanine are above the levels anticipated from the genetic code, and arginine, serine, leucine, cysteine, proline, and histidine are below such levels. Arginine plus lysine account for 11.0 percent of codons and aspartic acid plus glutamic acid account for 11.3 percent; thus the average charge is roughly neutral.Keywords
This publication has 5 references indexed in Scilit:
- Deviations from compositional randomness in eukaryotic and prokaryotic proteins: The hypothesis of selective-stochastic stability and a principle of charge conservationJournal of Molecular Evolution, 1975
- Arginine as an evolutionary intruder into protein synthesisBiochemical and Biophysical Research Communications, 1973
- Depression of Freezing Point by Glycoproteins from an Antarctic FishNature, 1973
- A STATISTICAL ANALYSIS OF THE AMINO ACID COMPOSITIONS OF PROTEINSInternational Journal of Peptide and Protein Research, 1973
- Non-Darwinian EvolutionScience, 1969