Stimulation of Muscle Protein Degradation and Prostaglandin E2Release by Leukocytic Pyrogen (Interleukin-1)
- 10 March 1983
- journal article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 308 (10), 553-558
- https://doi.org/10.1056/nejm198303103081002
Abstract
To clarify the mechanisms underlying the loss of body protein during fever and sepsis, we incubated rat muscles with highly purified human leukocytic pyrogen. This polypeptide, which appears identical to interleukin-1, is released by leukocytes and signals the onset of fever in the hypothalamus.Keywords
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