IgG antigens of the C gamma 2 and C gamma 3 homology regions interacting with rheumatoid factors.
- 1 October 1972
- journal article
- Vol. 12 (2), 177-84
Abstract
Haemagglutination inhibition experiments were used to study the interaction of several well-defined rheumatoid factors with pFc' fragments (≡Cγ3 homology regions) prepared from all four IgG subclasses. The results suggest that rheumatoid factors interact with antigens located in both homology regions of the Fc fragment. A minimum of four reactive regions is suggested—one in the Cγ3 region and three more in the Cγ2 region. This multiplicity of IgG antigens may contribute to the formation of rheumatoid factor-IgG complexes and therefore play a role in the complement-fixing activity of such complexes.This publication has 28 references indexed in Scilit:
- Immunoglobulin Peptide with Complement Fixing ActivityNature, 1969
- THE COVALENT STRUCTURE OF AN ENTIRE γG IMMUNOGLOBULIN MOLECULEProceedings of the National Academy of Sciences, 1969
- Stepwise cleavage of rabbit immunoglobin G by papain and isolation of four types of biologically active Fc fragmentsBiochemical Journal, 1969
- Genetic (Gm) Antigens associated with Subfragments from the Fc Fragment of Human Immunoglobulin GNature, 1969
- Subfragments from the Fc fragment of human immunoglobulin G. Isolation and physicochemical characterizationBiochemical Journal, 1968
- Heavy-Chain Subclasses of Human γG-Globulin. Peptide and Immunochemical Relationships*Biochemistry, 1967
- Presence of aggregated gamma-G-globulin in certain rheumatoid synovial effusions.1967
- Hidden rheumatoid factors with specificity for native γ globulinsArthritis & Rheumatism, 1966
- Gm(g)—A “New” Gamma-globulin FactorNature, 1966
- QUANTITATIVE DETERMINATIONS OF INCOMPLETE ANTI-D ANTIBODIES IN REACTION WITH ANTI-Gm FACTORSActa Pathologica Microbiologica Scandinavica, 1965