Histopathological analysis of initial cellular response in TLR‐2 deficient mice experimentally infected by Leishmania (L.) amazonensis
- 1 October 2010
- journal article
- Published by Wiley in International Journal of Experimental Pathology
- Vol. 91 (5), 451-459
- https://doi.org/10.1111/j.1365-2613.2010.00717.x
Abstract
Tegumentary leishmaniasis is an important public health problem in several countries. The capacity of the Leishmania species, at the initial moments of the infection, to invade and survive inside the host cells involves the interaction of surface molecules that are crucial in determining the evolution of the disease. Using C57BL/6 wild-type and TLR-2−/− mice infected with L. (L.) amazonensis, we demonstrated that TLR-2−/− mice presented eosinophilic granuloma in the ear dermis, different from C57BL/6 wild-type mice that presented a cellular profile characterized mainly by mononuclear cell infiltrates, besides neutrophils and eosinophils, during the two first week of infection. When the parasite load was evaluated, we found that the absence of TLR-2 lead to a significant reduction of the infection in deficient mice, when compared with C57BL/6 mice which were more susceptible to the infection. Using TLR-2 deficient mice, it was possible to show that the absence of this receptor determined the reduction of the parasite load and the recruitment of inflammatory cells during the two first weeks after L. (L.) amazonensis infection.Keywords
This publication has 47 references indexed in Scilit:
- Toll-like receptor 2 is important for the TH1 response to cutaneous sensitizationJournal of Allergy and Clinical Immunology, 2009
- In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand FliesScience, 2008
- Immunoregulatory roles of eosinophils: a new look at a familiar cellClinical & Experimental Allergy, 2008
- Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG PleurisyInfection and Immunity, 2007
- Mast cells at the host–pathogen interface: host-protectionversusimmune evasion in leishmaniasisClinical and Experimental Immunology, 2004
- High Levels of Susceptibility and T Helper 2 Response in MyD88-Deficient Mice Infected withLeishmania majorAre Interleukin-4 DependentInfection and Immunity, 2003
- MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll‐like receptor 2 signalingEuropean Journal of Immunology, 2003
- Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2Molecular and Biochemical Parasitology, 2003
- Immunity at the surface: Homeostatic mechanisms of the skin immune systemLife Sciences, 1996
- Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis InfectionImmunity, 1996