Chronic Kidney Disease in Aged Cats
- 11 February 2016
- journal article
- review article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 53 (2), 309-326
- https://doi.org/10.1177/0300985815622975
Abstract
Chronic kidney disease (CKD) is the most common metabolic disease of domesticated cats, with most affected cats being geriatric (>12 years of age). The prevalence of CKD in cats exceeds that observed in dogs, and the frequency of the diagnosis of CKD in cats has increased in recent decades. Typical histologic features include interstitial inflammation, tubular atrophy, and fibrosis with secondary glomerulosclerosis. In contrast to people and dogs, primary glomerulopathies with marked proteinuria are remarkably rare findings in cats. Although a variety of primary renal diseases have been implicated, the disease is idiopathic in most cats. Tubulointerstitial changes, including fibrosis, are present in the early stages of feline CKD and become more severe in advanced disease. A variety of factors—including aging, ischemia, comorbid conditions, phosphorus overload, and routine vaccinations—have been implicated as factors that could contribute to the initiation of this disease in affected cats. Factors that are related to progression of established CKD, which occurs in some but not all cats, include dietary phosphorus intake, magnitude of proteinuria, and anemia. Renal fibrosis, a common histologic feature of aged feline kidneys, interferes with the normal relationship between peritubular capillaries and renal tubules. Experimentally, renal ischemia results in morphologic changes similar to those observed in spontaneous CKD. Renal hypoxia, perhaps episodic, may play a role in the initiation and progression of this disease.Keywords
This publication has 100 references indexed in Scilit:
- Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic catsProceedings of the National Academy of Sciences of the United States of America, 2012
- Not so benign haematology: anaemia of the elderlyBritish Journal of Haematology, 2011
- Renal tubulointerstitial hypoxia: Cause and consequence of kidney dysfunctionClinical and Experimental Pharmacology and Physiology, 2011
- Bidirectional relationship between chronic kidney and periodontal disease: a study using structural equation modelingKidney International, 2011
- Periodontal disease as a risk marker in coronary heart disease and chronic kidney diseaseCurrent Opinion in Nephrology and Hypertension, 2010
- Effects of aging on glomerular function and number in living kidney donorsKidney International, 2010
- The Aging Kidney: Physiological ChangesAdvances in Chronic Kidney Disease, 2010
- The endothelial cell in ischemic acute kidney injury: implications for acute and chronic functionKidney International, 2007
- Ischemic acute renal failure: An inflammatory disease?Kidney International, 2004
- Dietary Protein Intake and the Progressive Nature of Kidney Disease:The New England Journal of Medicine, 1982