Advanced Development of the rF1V and rBV A/B Vaccines: Progress and Challenges
Open Access
- 17 October 2011
- journal article
- Published by Hindawi Limited in Advances in Preventive Medicine
- Vol. 2012, 1-14
- https://doi.org/10.1155/2012/731604
Abstract
The development of vaccines for microorganisms and bacterial toxins with the potential to be used as biowarfare and bioterrorism agents is an important component of the US biodefense program. DVC is developing two vaccines, one against inhalational exposure to botulinum neurotoxins A1 and B1 and a second forYersinia pestis, with the ultimate goal of licensure by the FDA under the Animal Rule. Progress has been made in all technical areas, including manufacturing, nonclinical, and clinical development and testing of the vaccines, and in assay development. The current status of development of these vaccines, and remaining challenges are described in this chapter.Keywords
Funding Information
- Chemical Biological Medical Systems-Joint Vaccine Acquisition Program (DAMD 17-98-C-8024, 5.10047-05-RDB, 1.1A0008-08_RDB)
This publication has 42 references indexed in Scilit:
- IL-17 Contributes to Cell-Mediated Defense against Pulmonary Yersinia pestis InfectionPublished by The American Association of Immunologists ,2011
- TNFα and IFNγ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plagueVaccine, 2010
- Inhalational Botulism in Rhesus Macaques Exposed to Botulinum Neurotoxin Complex Serotypes A1 and B1Clinical and Vaccine Immunology, 2010
- Antibody Protection against Botulinum Neurotoxin Intoxication in MiceInfection and Immunity, 2009
- Antibodies and cytokines independently protect against pneumonic plagueVaccine, 2008
- Modified Caspase-3 Assay Indicates Correlation of Caspase-3 Activity with Immunity of Nonhuman Primates to Yersinia pestis InfectionClinical and Vaccine Immunology, 2008
- Current challenges in the development of vaccines for pneumonic plagueExpert Review of Vaccines, 2008
- Development of In Vitro Correlate Assays of Immunity to Infection withYersinia pestisClinical and Vaccine Immunology, 2007
- PlagueThe Lancet, 2007
- Gamma Interferon, Tumor Necrosis Factor Alpha, and Nitric Oxide Synthase 2, Key Elements of Cellular Immunity, Perform Critical Protective Functions during Humoral Defense against Lethal PulmonaryYersinia pestisInfectionInfection and Immunity, 2006