HIPPURISTANOLS, CYTOTOXIC POLYOXYGENATED STEROIDS FROM THE GORGONIAN ISIS HIPPURIS
- 5 November 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 10 (11), 1647-1650
- https://doi.org/10.1246/cl.1981.1647
Abstract
Four new polyoxygenated steroids (4–7) containing a spiroketal function have been isolated from the gorgonian Isis hippuris. Their structures were determined by spectral correlation and by interconversion. Previously assigned configuration at the C-22 of hippurin-1 (3) was reversed by spectroscopic evidence. Two (4, 7) of the steroids exhibited potent in vitro anticancer activities.Keywords
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