UV Sterilization of Personal Protective Equipment with Idle Laboratory Biosafety Cabinets During the COVID-19 Pandemic
Open Access
- 27 March 2020
- preprint content
- other
- Published by Cold Spring Harbor Laboratory
Abstract
DISCLAIMER: This article does not represent the official recommendation of the Cleveland Clinic or Case Western Reserve University School of Medicine, nor has it yet been peer reviewed. We are releasing it early, pre-peer review, to allow for quick dissemination/vetting by the scientific/clinical community given the necessity for rapid conservation of personal protective equipment (PPE) during this dire global situation. We welcome feedback from the community.Personal protective equipment (PPE), including face shields, surgical masks, and N95 respirators, is crucially important to the safety of both patients and medical personnel, particularly in the event of an infectious pandemic. As the incidence of Coronavirus Disease (COVID-19) increases exponentially in the United States and worldwide, healthcare provider demand for these necessities is currently outpacing supply. As such, strategies to extend the lifespan of the supply of medical equipment as safely as possible are critically important. In the midst of the current pandemic, there has been a concerted effort to identify viable ways to conserve PPE, including decontamination after use. Some hospitals have already begun using UV-C light to decontaminate N95 respirators and other PPE, but many lack the space or equipment to implement existing protocols. In this study, we outline a procedure by which PPE may be decontaminated using ultraviolet (UV) radiation in biosafety cabinets (BSCs), a common element of many academic, public health, and hospital laboratories, and discuss the dose ranges needed for effective decontamination of critical PPE. We further discuss obstacles to this approach including the possibility that the UV radiation levels vary within BSCs. Effective decontamination of N95 respirator masks or surgical masks requires UV-C doses of greater than 1 Jcm−2, which would take a minimum of 4.3 hours per side when placing the N95 at the bottom of the BSCs tested in this study. Elevating the N95 mask by 48 cm (so that it lies 19 cm from the top of the BSC) would enable the delivery of germicidal doses of UV-C in 62 minutes per side. Effective decontamination of face shields likely requires a much lower UV-C dose, and may be achieved by placing the face shields at the bottom of the BSC for 20 minutes per side. Our results are intended to provide support to healthcare organizations looking for alternative methods to extend their reserves of PPE. We recognize that institutions will require robust quality control processes to guarantee the efficacy of any implemented decontamination protocol. We also recognize that in certain situations such institutional resources may not be available; while we subscribe to the general principle that some degree of decontamination is preferable to re-use without decontamination, we would strongly advise that in such cases at least some degree of on-site verification of UV dose delivery be performed.Keywords
This publication has 13 references indexed in Scilit:
- Radiation Biology for Medical PhysicistsPublished by Taylor & Francis Ltd ,2017
- Data AnalysisPublished by Springer Science and Business Media LLC ,2016
- Effects of Ultraviolet Germicidal Irradiation (UVGI) on N95 Respirator Filtration Performance and Structural IntegrityJournal of Occupational and Environmental Hygiene, 2015
- Effectiveness of Three Decontamination Treatments against Influenza Virus Applied to Filtering Facepiece RespiratorsAnnals of Work Exposures and Health, 2011
- A method to determine the available UV-C dose for the decontamination of filtering facepiece respiratorsJournal of Applied Microbiology, 2010
- Development of a Test System To Evaluate Procedures for Decontamination of Respirators Containing Viral DropletsApplied and Environmental Microbiology, 2009
- Inactivation of Viruses on Surfaces by Ultraviolet Germicidal IrradiationJournal of Occupational and Environmental Hygiene, 2007
- IntroductionPublished by Elsevier BV ,2005
- The Basic Principles of UV–Disinfection of WaterOzone: Science & Engineering, 1987
- Biological and Photo-Chemical Effects of High Energy, Electrostatically Produced Roentgen Rays and Cathode RaysJournal of Applied Physics, 1948