Synthesis and Secretion of Insulin-like Growth Factor II by a Leiomyosarcoma with Associated Hypoglycemia
- 1 December 1988
- journal article
- case report
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 319 (22), 1434-1440
- https://doi.org/10.1056/nejm198812013192202
Abstract
We describe a case of recurrent hypoglycemia apparently caused by secretion of insulin-like growth factor II (IGF-II) by a leiomyosarcoma. A 67-year-old woman presented with recurrent severe hypoglycemia and a large mass in the thorax. During hypoglycemia, plasma cortisol was elevated, but insulin and growth hormone levels were low. After resection of a large leiomyosarcoma, the hypoglycemia resolved.Keywords
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