Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training
- 6 February 2009
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 323 (5915), 800-802
- https://doi.org/10.1126/science.1166102
Abstract
Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.This publication has 25 references indexed in Scilit:
- Transfer of Learning After Updating Training Mediated by the StriatumScience, 2008
- Improving fluid intelligence with training on working memoryProceedings of the National Academy of Sciences of the United States of America, 2008
- Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memoryNature Neuroscience, 2007
- Frontal and Temporal Dopamine Release during Working Memory and Attention Tasks in Healthy Humans: a Positron Emission Tomography Study Using the High-Affinity Dopamine D2Receptor Ligand [11C]FLB 457Journal of Neuroscience, 2005
- Increased prefrontal and parietal activity after training of working memoryNature Neuroscience, 2003
- Dopamine Depletion and In Vivo Binding of PET D1 Receptor Radioligands: Implications for Imaging Studies in SchizophreniaNeuropsychopharmacology, 2003
- Training of Working Memory in Children With ADHDJournal of Clinical and Experimental Neuropsychology, 2002
- Working-memory capacity explains reasoning ability—and a little bit moreIntelligence, 2002
- “What”—Then—“Where” in Visual Working Memory: An Event-Related fMRI StudyJournal of Cognitive Neuroscience, 1999
- Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus MonkeyScience, 1979