Avian influenza H5N1 viral and bird migration networks in Asia
- 22 December 2014
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 112 (1), 172-177
- https://doi.org/10.1073/pnas.1405216112
Abstract
The spatial spread of the highly pathogenic avian influenza virus H5N1 and its long-term persistence in Asia have resulted in avian influenza panzootics and enormous economic losses in the poultry sector. However, an understanding of the regional long-distance transmission and seasonal patterns of the virus is still lacking. In this study, we present a phylogeographic approach to reconstruct the viral migration network. We show that within each wild fowl migratory flyway, the timing of H5N1 outbreaks and viral migrations are closely associated, but little viral transmission was observed between the flyways. The bird migration network is shown to better reflect the observed viral gene sequence data than other networks and contributes to seasonal H5N1 epidemics in local regions and its large-scale transmission along flyways. These findings have potentially far-reaching consequences, improving our understanding of how bird migration drives the periodic reemergence of H5N1 in Asia.Keywords
This publication has 52 references indexed in Scilit:
- Interventions for avian influenza A (H5N1) risk management in live bird market networksProceedings of the National Academy of Sciences, 2013
- Bayesian Phylogenetics with BEAUti and the BEAST 1.7Molecular Biology and Evolution, 2012
- Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humansProceedings of the National Academy of Sciences, 2011
- Migratory flyway and geographical distance are barriers to the gene flow of influenza virus among North American birdsEcology Letters, 2011
- Effects of influenza A virus infection on migrating mallard ducksProceedings Of The Royal Society B-Biological Sciences, 2008
- Mapping H5N1 highly pathogenic avian influenza risk in Southeast AsiaProceedings of the National Academy of Sciences, 2008
- Predicting the global spread of H5N1 avian influenzaProceedings of the National Academy of Sciences, 2006
- Emergence and predominance of an H5N1 influenza variant in ChinaProceedings of the National Academy of Sciences, 2006
- MUSCLE: multiple sequence alignment with high accuracy and high throughputNucleic Acids Research, 2004
- A new look at the statistical model identificationIEEE Transactions on Automatic Control, 1974