Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation
- 2 June 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 244 (4908), 1057-1062
- https://doi.org/10.1126/science.2727693
Abstract
Neurotransmitter receptors are usually restricted to neuronal cells, but the signaling pathways activated by these receptors are widely distributed in both neural and non-neural cells. The functional consequences of activating a brain-specific neurotransmitter receptor, the serotonin 5HT1c receptor, in the unnatural environment of a fibroblast were examined. Introduction of functional 5HT1c receptors into NIH 3T3 cells results, at high frequency, in the generation of transformed foci. Moreover, the generation and maintenance of transformed foci requires continued activation of the serotonin receptor. In addition, the injection of cells derived from transformed foci into nude mice results in the generation of tumors. The serotonin 5HT1c receptor therefore functions as a protooncogene when expressed in NIH 3T3 fibroblasts.Keywords
This publication has 30 references indexed in Scilit:
- The mas oncogene encodes an angiotensin receptorNature, 1988
- 5-Hydroxytryptamine Receptor SubtypesAnnual Review of Neuroscience, 1988
- Overproduction of protein kinase C causesdisordered growth control in rat fibroblastsCell, 1988
- Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotoninNature, 1987
- Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxinNature, 1987
- Pertussis Toxin-Sensitive Pathway in the Stimulation of c- myc Expression and DNA Synthesis by BombesinScience, 1986
- Stimulation of connective tissue cell growth by substance P and substance KNature, 1985
- Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateNature, 1983
- Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in cultureNature, 1983
- Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neuronesNature, 1982