Acetylcholine and the Physiology of the Nervous System

Abstract
Evidence is reviewed to support the theory that acetylcholine intervention is a primary event essential in synaptic and neuromuscular transmission. Acetylcholine metabolism is intimately concerned with electrical changes everywhere at neuronal surfaces and is only quantitatively more important at synapses. By denying special synaptic mechanisms, this conciliates "chemical" and "electrical" theories.