Engineering Polymersome Protocells
- 8 June 2011
- journal article
- perspective
- Published by American Chemical Society (ACS) in The Journal of Physical Chemistry Letters
- Vol. 2 (13), 1612-1623
- https://doi.org/10.1021/jz200640x
Abstract
The field of biomimicry is embracing the construction of complex assemblies that imitate both biological structure and function. Advancements in the design of these mimetics have generated a growing vision for creating an artificial cell or protocell. Polymersomes are vesicles that can be made from synthetic, biological, or hybrid polymers and can be used as a model template to build cell-like structures. In this perspective, we discuss various areas where polymersomes have been used to mimic cell functions as well as areas in which the synthetic flexibility of polymersomes would make them ideal candidates for a biomembrane mimetic. Designing a polymersome that comprehensively displays the behaviors discussed herein has the potential to lead to the development of an autonomous, responsive particle that resembles the intelligence of a biological cell.Keywords
This publication has 106 references indexed in Scilit:
- Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responsesNature Materials, 2011
- Tunable Leuko-polymersomes That Adhere Specifically to Inflammatory MarkersLangmuir, 2010
- A Generalized System for Photoresponsive Membrane Rupture in PolymersomesAdvanced Functional Materials, 2010
- Synthetic Protocells to Mimic and Test Cell FunctionAdvanced Materials, 2009
- Porous Polymersomes with Encapsulated Gd‐Labeled Dendrimers as Highly Efficient MRI Contrast AgentsAdvanced Functional Materials, 2009
- Toward an Artificial Golgi: Redesigning the Biological Activities of Heparan Sulfate on a Digital Microfluidic ChipJournal of the American Chemical Society, 2009
- Synthesis and Self-Assembly of RGD-Functionalized PEO-PB AmphiphilesBiomacromolecules, 2009
- In Vivo Dendritic Cell Tracking Using Fluorescence Lifetime Imaging and Near-Infrared-Emissive PolymersomesMolecular Imaging & Biology, 2009
- Paramagnetic Porous PolymersomesLangmuir, 2008
- Cell‐free synthetic biology: a bottom‐up approach to discovery by designMolecular Systems Biology, 2006