Oncologic Efficacy Is Not Compromised, and May Be Improved with Minimally Invasive Esophagectomy
- 31 March 2011
- journal article
- conference paper
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American College of Surgeons
- Vol. 212 (4), 560-566
- https://doi.org/10.1016/j.jamcollsurg.2010.12.042
Abstract
BACKGROUND: Major morbidity and mortality rates continue to be high in large series of transthoracic esophagectomies. Minimally invasive approaches are being increasingly used. We compare our growing series of minimally invasive (combined thoracoscopic and laparoscopic) esophagectomies (MIEs) with a series of open transthoracic esophagectomies. STUDY DESIGN: We identified 65 patients who underwent an MIE with thoracoscopy/laparotomy (n = 11), Ivor Lewis (n = 2), or 3-hole approach (n = 52). These patients were compared with 53 patients who underwent open Ivor-Lewis esophagectomy (n = 15) or 3-hole esophagectomy (n = 38) over the past 10 years. RESULTS: The MIE and open groups were similar regarding gender and average age. The majority of patients in the open group underwent neoadjuvant chemoradiation therapy (81%); a significantly smaller (43%) number of patients in the MIE group underwent neoadjuvant therapy (p < 0.0001). Regarding oncologic efficacy, 97% and 94% of patients in both groups underwent R0 resections. Patients undergoing MIE had a significant increase in the number of harvested lymph nodes (median 20 vs 9; p < 0.0001). Length of stay was significantly decreased in patients who underwent MIE (8.5 days vs 16 days; p = 0.002). Finally, there were significantly fewer serious complications (grades 3-5) in the MIE group (19% vs 48%; p = 0.0008). CONCLUSIONS: In this initial report of a single-institution series of MIE, we demonstrate that oncologic efficacy is not compromised and may actually be improved with a significantly increased number of harvested LNs. We also demonstrate that this approach is associated with fewer serious complications and a significant decrease in the length of postoperative hospital stay. (J Am Coll Surg 2011;212:560-568. (C) 2011 by the American College of Surgeons)This publication has 19 references indexed in Scilit:
- Open Versus Minimally Invasive EsophagectomyAnnals of Surgery, 2010
- Is minimally invasive surgery beneficial in the management of esophageal cancer? A meta-analysisSurgical Endoscopy, 2010
- Prognostic Significance of Lymph Node Metastases and Ratio in Esophageal CancerJournal of Surgical Research, 2008
- The Number of Metastatic Lymph Nodes and the Ratio Between Metastatic and Examined Lymph Nodes Are Independent Prognostic Factors in Esophageal Cancer Regardless of Neoadjuvant Chemoradiation or Lymphadenectomy ExtentAnnals of Surgery, 2008
- Effect of the number of lymph nodes sampled on postoperative survival of lymph node‐negative esophageal cancerCancer, 2008
- Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trialThe Lancet Oncology, 2005
- Classification of Surgical ComplicationsAnnals of Surgery, 2004
- A Comparison of Laparoscopically Assisted and Open Colectomy for Colon CancerNew England Journal of Medicine, 2004
- Extended Transthoracic Resection Compared with Limited Transhiatal Resection for Adenocarcinoma of the EsophagusNew England Journal of Medicine, 2002
- Abdominal wall metastasis and peritoneal carcinomatosis after laparoscopic assisted colectomy for colon cancerEuropean Journal of Surgical Oncology, 1995