Hyponatremia, Hypophosphatemia, and Hypouricemia in a Girl With Macrophage Activation Syndrome
- 1 December 2006
- journal article
- case report
- Published by American Academy of Pediatrics (AAP)
- Vol. 118 (6), 2557-2560
- https://doi.org/10.1542/peds.2006-1127
Abstract
Macrophage activation syndrome, a life-threatening complication of rheumatic disorders, is accompanied by the overproduction of cytokines. We describe a girl with macrophage activation syndrome complicating systemic-onset juvenile arthritis who developed hyponatremia, hypophosphatemia, and hypouricemia associated with a high level of serum tumor necrosis factor α. Renal proximal tubule dysfunction was considered to be the cause, which may be attributable to tumor necrosis factor α.Keywords
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