Chemotherapy for Angiosarcoma of the Breast: Case Report of 30-Year Survival and Analysis of the Literature
- 1 January 1994
- journal article
- case report
- Published by Taylor & Francis Ltd in Cancer Investigation
- Vol. 12 (2), 145-155
- https://doi.org/10.3109/07357909409024870
Abstract
Angiosarcoma of the breast is a rare and highly malignant neoplasm with few long-term survivors. Little is known about the effects of chemotherapy for patients with disseminated disease or its role in the adjuvant setting. We report the case of a patient with metastatic angiosarcoma of the breast who achieved a long-term clinical and pathological remission after treatment with methotrexate. The 30-year course of her disease is the longest reported survival with documented metastatic angiosarcoma of the breast. Analysis of the role of chemotherapy in the adjuvant setting and its effects in relation to histological subtype is undertaken. Adjuvant chemotherapy for patients with poorly differentiated angiosarcoma of the breast results in a higher proportion of patients relapse-free (29.2%) compared to patients not receiving adjuvant chemotherapy (4.4%) (p < 0.05). Patients with well-differentiated tumors do not appear to derive benefit from adjuvant chemotherapy. The effects for patients with disseminated disease are reported.Keywords
This publication has 22 references indexed in Scilit:
- Mammary angiosarcoma: The prognostic significance of tumor differentiationCancer, 1988
- Angiosarcoma of the breast: Long‐term survival following adjuvant chemotherapyJournal of Surgical Oncology, 1988
- Angiosarcoma of the BreastArchives of Surgery, 1986
- Multimodality therapy in the management of angiosarcoma of the breastCancer, 1982
- Vascular tumors of the mammary glandVirchows Archiv A Pathological Anatomy and Histopathology, 1981
- Angiosarcoma and other vascular tumors of the breastThe American Journal of Surgical Pathology, 1981
- Feasibility of combined modality therapy for localized high-grade soft tissue sarcomas in adultsInternational Journal of Radiation Oncology*Biology*Physics, 1979
- Haemangiosarcoma of breastThe Journal of Pathology and Bacteriology, 1968
- Hemangiosarcoma of the breastCancer, 1965
- Hæmangioblastoma of the breast associated with pregnancyBritish Journal of Surgery, 1959