New ideas in biomaterials science—a path to engineered biomaterials
- 1 July 1993
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 27 (7), 837-850
- https://doi.org/10.1002/jbm.820270702
Abstract
Our existing biomaterials, although demonstrating generally satisfactory clinical performance, were developed based upon a trial-and-error optimization approach rather than being engineered to produce the desired interfacial reaction. Most biomaterials exhibit a nonspecific biological reaction, with sluggish kinetics and a broad spectrum of active processes simultaneously occurring. This article describes materials science, nanotechnology, and molecular biology techniques that may permit the synthesis of precisely engineered surfaces. Such surfaces might demonstrate rapid, precise reactions with proteins and cells. This opens the question, “what type of specific surface bioreactions do we want?” New thoughts on biocompatibility are presented that may be helpful in the design of specific surfaces yielding precise, defined biological responses. © 1993 John Wiley & Sons, Inc.Keywords
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