Intracellular microbes and haemophagocytosis
Open Access
- 13 October 2008
- journal article
- review article
- Published by Hindawi Limited in Cellular Microbiology
- Vol. 10 (11), 2151-2158
- https://doi.org/10.1111/j.1462-5822.2008.01192.x
Abstract
Haemophagocytosis (hemophagocytosis) is the phenomenon of activated macrophage consumption of red and white blood cells, including professional phagocytes and lymphocytes. It can occur in patients with severe cases of intracellular microbial infection, including avian influenza, leishmaniasis, tuberculosis and typhoid fever. While well‐known to physicians since at least the mid‐1800s, haemophagocytosis has been little studied due to a paucity of tractable animal and cell culture models. Recently, haemophagocytosis has been described in a mouse model of typhoid fever, and it was noted that the infectious agent, Salmonella enterica, resides within haemophagocytic macrophages in mice. In addition, a cell culture model for haemophagocytosis revealed that S. enterica preferentially replicate in haemophagocytic macrophages. This review describes how, at the molecular and cellular levels, S. enterica may promote and take advantage of haemophagocytosis to establish long‐term systemic infections in mammals. The role, relevance and possible molecular mechanisms of haemophagocytosis are discussed within the context of other microbial infections and of genetic deficiencies in which haemophagocytosis occurs and is associated with morbidity.Keywords
This publication has 69 references indexed in Scilit:
- Host Transmission of Salmonella enterica Serovar Typhimurium Is Controlled by Virulence Factors and Indigenous Intestinal MicrobiotaInfection and Immunity, 2008
- Analysis of Cells Targeted by Salmonella Type III Secretion In VivoPLoS Pathogens, 2007
- Hemophagocytic Macrophages Harbor Salmonella enterica during Persistent InfectionPLoS Pathogens, 2007
- Iron acquisition within host cells and the pathogenicity of LeishmaniaCellular Microbiology, 2007
- Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in miceThe Journal of Experimental Medicine, 2007
- Slc11a1, Formerly Nramp1, Is Expressed in Dendritic Cells and Influences Major Histocompatibility Complex Class II Expression and Antigen-Presenting Cell FunctionInfection and Immunity, 2007
- Caspase-1-Mediated Activation of Interleukin-1β (IL-1β) and IL-18 Contributes to Innate Immune Defenses againstSalmonella entericaSerovar Typhimurium InfectionInfection and Immunity, 2006
- Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesisThe Journal of Experimental Medicine, 2006
- Genome-Wide Screen for Salmonella Genes Required for Long-Term Systemic Infection of the MousePLoS Pathogens, 2006
- An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorderBlood, 2004