A Highly Selective Fluorescent Probe for Thiol Bioimaging
- 7 December 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (1), 37-40
- https://doi.org/10.1021/ol702539v
Abstract
A new fluorescent turn-on probe (3) for the selective sensing and bioimaging of thiols is reported. In aqueous buffer solutions at physiological pH, thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the red-emissive donor−acceptor fluorophore (4). The probe displays excellent immunity to interference from nitrogen and oxygen nucleophiles and the imaging of thiols in living cells is demonstrated.Keywords
This publication has 17 references indexed in Scilit:
- 2,4‐Dinitrobenzenesulfonyl Fluoresceins as Fluorescent Alternatives to Ellman's Reagent in Thiol‐Quantification Enzyme AssaysAngewandte Chemie, 2005
- Analytical determination of homocysteine: a reviewTalanta, 2003
- Design and Synthesis of Chemiluminescent Probes for the Detection of Cholinesterase ActivityJournal of the American Chemical Society, 2002
- HomocysteineThe International Journal of Biochemistry & Cell Biology, 2000
- Homocysteine and Cardiovascular DiseaseAnnual Review of Medicine, 1998
- Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery DiseaseThe New England Journal of Medicine, 1997
- Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's diseaseNeuroscience Letters, 1990
- A Rapid Determination of Individual Mercaptans in Gasoline Boiling Range Stocks.Analytical Chemistry, 1965
- Catalytic Activity of Cysteine and Related Compounds in Iodine-Azide ReactionAnalytical Chemistry, 1953
- Determination of Disulfides in Presence of ThiolsAnalytical Chemistry, 1953