Caveolin-1: An Oxidative Stress-Related Target for Cancer Prevention
Open Access
- 4 May 2017
- journal article
- review article
- Published by Hindawi Limited in Oxidative Medicine and Cellular Longevity
- Vol. 2017, 1-20
- https://doi.org/10.1155/2017/7454031
Abstract
Aberrant oxidative metabolism is one of the hallmarks of cancer. Reactive species overproduction could promote carcinogenesis via inducing genetic mutations and activating oncogenic pathways, and thus, antioxidant therapy was considered as an important strategy for cancer prevention and treatment. Caveolin-1 (Cav-1), a constituent protein of caveolae, has been shown to mediate tumorigenesis and progression through oxidative stress modulation recently. Reactive species could modulate the expression, degradation, posttranslational modifications, and membrane trafficking of Cav-1, while Cav-1-targeted treatments could scavenge the reactive species. More importantly, emerging evidences have indicated that multiple antioxidants could exert antitumor activities in cancer cells and protective activities in normal cells by modulating the Cav-1 pathway. Altogether, these findings indicate that Cav-1 may be a promising oxidative stress-related target for cancer antioxidant prevention. Elucidating the underlying interaction mechanisms between oxidative stress and Cav-1 is helpful for enhancing the preventive effects of antioxidants on cancer, for improving clinical outcomes of antioxidant-related therapeutics in cancer patients, and for developing Cav-1 targeted drugs. Herein, we summarize the available evidence of the roles of Cav-1 and oxidative stress in tumorigenesis and development and shed novel light on designing strategies for cancer prevention or treatment by utilizing the interaction mode between Cav-1 and oxidative stress.Keywords
Funding Information
- GZUCMTorch Program (XH20140108, 2016KYTD10, 2016M592585, A1-3002-16-111-003, A1-AFD018161Z1510, 2014A020221047, 201506010098, 81402173, 81573651)
This publication has 152 references indexed in Scilit:
- The transmembrane domain of caveolin-1 exhibits a helix–break–helix structureBiochimica et Biophysica Acta (BBA) - Biomembranes, 2012
- Altered Mitochondrial Function and Metabolic Inflexibility Associated with Loss of Caveolin-1Cell Metabolism, 2012
- CAVEOLIN-1: Role in Cell SignalingPublished by Springer Science and Business Media LLC ,2012
- Dietary oxidative stress and antioxidant defense with an emphasis on plant extract administrationCell Stress and Chaperones, 2011
- Caveolin-1 Deficiency Causes Cholesterol-Dependent Mitochondrial Dysfunction and Apoptotic SusceptibilityCurrent Biology, 2011
- Regulation of cancer cell metabolismNature Reviews Cancer, 2011
- Activity of the multikinase inhibitor dasatinib against ovarian cancer cellsBritish Journal of Cancer, 2009
- Growth suppression by ursodeoxycholic acid involves caveolin-1 enhanced degradation of EGFRBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
- Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative ApoptosisCancer Cell, 2008
- Caveolin Isoforms Differ in Their N-terminal Protein Sequence and Subcellular Distribution. IDENTIFICATION AND EPITOPE MAPPING OF AN ISOFORM-SPECIFIC MONOCLONAL ANTIBODY PROBEPublished by Elsevier BV ,1995