Incidence, risk factors, and outcomes of Fusobacterium species bacteremia
Open Access
- 5 June 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Infectious Diseases
- Vol. 13 (1), 264
- https://doi.org/10.1186/1471-2334-13-264
Abstract
Fusobacterium species (spp.) bacteremia is uncommon and has been associated with a variety of clinical presentations. We conducted a retrospective, population based study to determine the relative proportion of species in this genus causing bacteremia and the risk factors for infection and adverse clinical outcomes. All cases of Fusobacterium spp. bacteremia detected at a regional microbiology laboratory serving outpatient and acute care for a population of approximately 1.3 million people over 11 years were identified from a computerized database. Clinical data on these cases was extracted from an administrative database and analyzed to determine underlying risk factors for and outcomes of infection. There were 72 incident cases of Fusobacterium spp. bacteremia over the study period (0.55 cases/100,000 population per annum). F. nucleatum was the most frequent species (61%), followed by F. necrophorum (25%). F. necrophorum bacteremia occurred in a younger population without underlying comorbidities and was not associated with mortality. F. nucleatum bacteremia was found in an older population and was associated with underlying malignancy or receiving dialysis. Death occurred in approximately 10% of F. nucleatum cases but causality was not established in this study. Fusobacterium spp. bacteremia in our community is uncommon and occurs in approximately 5.5 cases per million population per annum. F. necrophorum occurred in an otherwise young healthy population and was not associated with any mortality. F. nucleatum was found primarily in older patients with chronic medical conditions and was associated with a mortality of approximately 10%. Bacteremias from other Fusobacterium spp. were rare.Keywords
This publication has 31 references indexed in Scilit:
- Artritis séptica por Fusobacterium nucleatum en paciente inmunocompetenteReumatología Clínica, 2012
- The distinct category of healthcare associated bloodstream infectionsBMC Infectious Diseases, 2012
- Characteristics and outcomes of Fusobacterium nucleatum bacteremia—a 6-year experience at a tertiary care hospital in northern TaiwanDiagnostic Microbiology and Infectious Disease, 2011
- Epidemiological characteristics of infections caused by Bacteroides, Prevotella and Fusobacterium species: A prospective observational studyAnaerobe, 2011
- Case 10-2010New England Journal of Medicine, 2010
- Term Stillbirth Caused by Oral Fusobacterium nucleatumObstetrics & Gynecology, 2010
- Fusobacterial infections: Clinical spectrum and incidence of invasive diseaseJournal of Infection, 2008
- Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's SyndromeClinical Microbiology Reviews, 2007
- Detection of Fusobacterium necrophorum subsp. funduliforme in tonsillitis in young adults by real-time PCRClinical Microbiology & Infection, 2007
- Blindness From Septic Thrombophlebitis of the Orbit and Cavernous SinusCaused by Fusobacterium nucleatumAmerican Journal of Ophthalmology, 2004