INDIVIDUALIZATION OF FACTOR VIII DOSAGE
- 1 April 1984
- journal article
- Published by Hindawi Limited in Journal of Clinical Pharmacy & Therapeutics
- Vol. 9 (2), 95-103
- https://doi.org/10.1111/j.1365-2710.1984.tb01065.x
Abstract
The usefulness of a calculator programme that enables individualization of the dosage of Factor VIII, based on the concentration-time data measured after a test-dose, was assessed. The programme was tested in 12 haemophiliacs who required multiple-dose treatment with Factor VIII. Individual kinetic parameters were estimated in each patient from the plasma level data following the test-dose. Then, each patient received the multiple dose treatment with Factor VIII according to the dosage regimen suggested by the calculator programme. The time-curve of Factor VIII plasma levels at steady state was predicted by using the kinetic variables previously estimated. The plasma levels of Factor VIII were measured in all patients at steady state. As a result, good agreement between predicted and measured steady state concentrations was observed (r2 = 0.9797; P less than 0.001). The calculator programme tested in the present study appears to be a useful tool for individualizing the dosage regimen of Factor VIII in haemophiliacs.Keywords
This publication has 13 references indexed in Scilit:
- AIDSand Preventive Treatment in HemophiliaNew England Journal of Medicine, 1983
- T-Lymphocyte Subpopulations in Patients with Classic Hemophilia Treated with Cryoprecipitate and Lyophilized ConcentratesNew England Journal of Medicine, 1983
- Impaired Cell-Mediated Immunity in Patients with Classic HemophiliaNew England Journal of Medicine, 1983
- Test dose for predicting high-dose methotrexate infusionsClinical Pharmacology & Therapeutics, 1983
- Accuracy of Using Pre- and Postdose Gentamicin Serum Concentrations to Estimate Pharmacokinetic Parameters and Adjust Doses in Children and AdolescentsTherapeutic Drug Monitoring, 1981
- CALCULATING THE DOSE OF FACTOR VIII IN THE MANAGEMENT OF HAEMOPHILIABritish Journal of Haematology, 1981
- A Model for Dosing Gentamicin in Children and Adolescents that Adjusts for Tissue Accumulation with Continuous Dosing1Clinical Pharmacokinetics, 1980
- Characteristics of Various Factor VIII Concentrates used in Treatment of Haemophilia ABritish Journal of Haematology, 1977
- Kinetic model for gentamicin dosing with the use of individual patient parametersCancer Cell, 1977
- Pharmacokinetics of dosing regimens which utilize multiple intravenous infusions: Gentamicin in burn patientsJournal of Pharmacokinetics and Biopharmaceutics, 1976