Exposure of Humans to Complex Chemical Mixtures: Hazard Identification and Risk Assessment
- 1 January 1998
- book chapter
- conference paper
- Published by Springer Science and Business Media LLC
- Vol. 20, 363-373
- https://doi.org/10.1007/978-3-642-46856-8_32
Abstract
A complex chemical mixture is defined as a mixture that consists of tens, hundreds or thousands of chemicals, and of which the composition is qualitatively and quantitatively not fully known. In contrast, a simple mixture consists of a relatively small number of chemicals, say ten or less, and the composition of which is fully known. In the present paper a number of options for hazard identification and risk assessment of complex chemical mixtures is discussed, and a scheme aimed at selecting the most appropriate approach for each (type of) complex mixture is presented. A conspicuous element of this scheme is the dichotomy of complex mixtures into mixtures that are readily available and mixtures that are virtually unavailable for testing in their entirety. Another characteristic aspect of the scheme is the inclusion of the “top-ten” and “pseudo top-ten” approaches, which in essence are ways to select the, say ten, most risky chemicals or pseudocomponents to be dealt with as a simple chemical mixture.Keywords
This publication has 18 references indexed in Scilit:
- Subacute Toxicity of a Mixture of Nine Chemicals in Rats: Detecting Interactive Effects with a Fractionated Two-Level Factorial DesignFundamental and Applied Toxicology, 1997
- Strategies for toxicological evaluation of mixturesFood and Chemical Toxicology, 1996
- PrefaceFood and Chemical Toxicology, 1996
- Chemical mixtures released from hazardous waste sites: implications for health risk assessmentToxicology, 1995
- Chemical mixtures from a public health perspective: the importance of research for informed decision makingToxicology, 1995
- Toxicology of chemical mixtures: challenges for today and the futureToxicology, 1995
- Chemical mixtures: challenge for toxicology and risk assessmentToxicology, 1995
- The application of physiologically based pharmacokinetic/ pharmacodynamic (PBPK/PD) modeling for exploring risk assessment approaches of chemical mixturesToxicology Letters, 1995
- Feasibility of Composite Workplace Standards for Chemical and/or Physical Workplace FactorsPublished by Springer Science and Business Media LLC ,1988
- Safety evaluation of yeast grown on hydrocarbons. III. Two-year feeding and multigeneration study in rats with yeast grown on gas oilFood and Cosmetics Toxicology, 1971