Reirradiation to the abdomen for gastrointestinal malignancies
Open Access
- 18 November 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Radiation Oncology
- Vol. 4 (1), 55
- https://doi.org/10.1186/1748-717x-4-55
Abstract
Background Reirradiation to the abdomen could potentially play a role in palliation of symptoms or local control in patients with gastrointestinal malignancies. Our goal was to retrospectively determine rates of toxicity, freedom from local progression and overall survival in gastrointestinal cancer patients treated with reirradiation to the abdomen. Methods Between November 2002 and September 2008, 13 patients with a prior history of abdominal radiotherapy (median dose 45 Gy) were treated with reirradiation for recurrent or metastatic gastrointestinal malignancies. The median interval between the two courses of radiotherapy was 26 months. Patients were treated with a hyperfractionated accelerated regimen, using 1.5 Gy fractions twice daily, with a median dose of 30 Gy (range 24-48 Gy). Concurrent chemotherapy was administered to 8 (62%) patients. Results The 1-year rate of freedom from local progression was 50%, and the median duration of freedom from local progression was 14 months. The 1-year rate of overall survival was 62%, and the median duration of overall survival was 14 months. One patient developed grade 3 acute toxicity (abdominal pain and gastrointestinal bleeding), requiring hospitalization during radiotherapy; subsequently, that patient experienced a grade 4 late toxicity (gastrointestinal bleeding). No other patients developed grade 3-4 acute or late toxicity or required hospitalization during radiotherapy. Conclusion Hyperfractionated accelerated reirradiation to the abdomen was well-tolerated with low rates of acute and late toxicity. Reirradiation could play a role in providing a limited duration of local control in gastrointestinal cancer patients with a history of prior abdominal radiotherapy.Keywords
This publication has 18 references indexed in Scilit:
- Hyperfractionated Accelerated Radiotherapy for Rectal Cancer in Patients With Prior Pelvic IrradiationInternational Journal of Radiation Oncology*Biology*Physics, 2009
- The Pattern of Failure After Reirradiation of Recurrent Squamous Cell Head and Neck Cancer: Implications for Defining the TargetsInternational Journal of Radiation Oncology*Biology*Physics, 2009
- Prognostic Factors for Survival After Salvage Reirradiation of Head and Neck CancerJournal of Clinical Oncology, 2009
- Randomized Trial of Postoperative Reirradiation Combined With Chemotherapy After Salvage Surgery Compared With Salvage Surgery Alone in Head and Neck CarcinomaJournal of Clinical Oncology, 2008
- Reirradiation of recurrent breast cancer with and without concurrent chemotherapyRadiation Oncology, 2008
- Phase II Study of Low-Dose Paclitaxel and Cisplatin in Combination With Split-Course Concomitant Twice-Daily Reirradiation in Recurrent Squamous Cell Carcinoma of the Head and Neck: Results of Radiation Therapy Oncology Group Protocol 9911Journal of Clinical Oncology, 2007
- Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: A multicentric phase II studyInternational Journal of Radiation Oncology*Biology*Physics, 2006
- Long‐term results of reirradiation for patients with recurrent rectal carcinomaCancer, 2002
- Reirradiation for rectal cancer and surgical resection after ultra high dosesInternational Journal of Radiation Oncology*Biology*Physics, 1993
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958