A facile solid-state synthesis andin vitroantimicrobial activities of some 2,6-diarylpiperidin/tetrahydrothiopyran and tetrahydropyran-4-one oximes
Open Access
- 1 June 2009
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Enzyme Inhibition and Medicinal Chemistry
- Vol. 24 (3), 669-675
- https://doi.org/10.1080/14756360802323902
Abstract
Some 2,6-diarylpiperidin/tetrahydrothiopyran/tetrahydropyran-4-one oximes were synthesized in dry media under microwave irradiation and were evaluated for their in vitro antibacterial activity against clinically isolated bacterial strains i.e. S.aureus, β-H.Streptococcus, E.coli, P.aeruginosa, S.typhii and in vitro antifungal activities against fungal strains i.e. C.albicans, Rhizopus, A.niger and A.flavus. Structure-activity relationships for the synthesized compounds showed that compounds 12 and 15 exerted excellent antibacterial activity against all the tested bacterial strains except 15 against S.aureus and β-H.streptococcus. Against C.albicans and A.flavus, compound 15 exerted potent antifungal activities while against Rhizopus, compound 16 showed promising activity.Keywords
This publication has 22 references indexed in Scilit:
- Design, synthesis, characterization, antibacterial and antifungal activities of a novel class of 5,7-diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazolesJournal of Enzyme Inhibition and Medicinal Chemistry, 2008
- Conversion of Piperidine-4-ones into [1,4]-diazepan-5-ones under Microwave Irradiation Using a Silica Gel Supported NaHSO4 CatalystJournal of Chemical Research, 2007
- A convenient ‘one-pot’ synthesis andin vitromicrobiological evaluation of novel 2,7-diaryl-[1,4]-diazepan-5-onesJournal of Enzyme Inhibition and Medicinal Chemistry, 2007
- Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. III. Synthesis of (.+-.)-N-12-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1-yl)butyll-N-methylbenzamides and Evaluation of NK1-NK2 Dual Antagonistic Activities.CHEMICAL & PHARMACEUTICAL BULLETIN, 1998
- Conformational Studies of Some 1-Hetera-2,6-diphenylcyclohexan-4-one Oximes Using NMR Spectra-Evidence for Boat Form Contributions to trans-2,6-Diphenyl SystemsBulletin of the Chemical Society of Japan, 1997
- 13C and 1H NMR spectral studies of some piperidin‐4‐one oximesMagnetic Resonance in Chemistry, 1986
- Potential anticancer agents. XXVI. Spin Labelled NitrosoureasJournal für Praktische Chemie, 1985
- Alkylation of Ketones and Aldehydes via their Nitrogen DerivativesSynthesis, 1983
- Studies on the Mechanism of Oxime and Semicarbazone Formation1Journal of the American Chemical Society, 1959
- The Preparation of Some Piperidine Derivatives by the Mannich ReactionJournal of the American Chemical Society, 1948