Aerosol Deposition in Health and Disease
- 1 June 2012
- journal article
- review article
- Published by Mary Ann Liebert Inc in Journal of Aerosol Medicine and Pulmonary Drug Delivery
- Vol. 25 (3), 140-147
- https://doi.org/10.1089/jamp.2011.0916
Abstract
The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. This article reviews the main mechanisms affecting the transport and deposition of inhaled aerosol in the human lung. Aerosol deposition in both the healthy and diseased lung is described mainly based on the results of human studies using nonimaging techniques. This is followed by a discussion of the effect of flow regime on aerosol deposition. Finally, the link between therapeutic effects of inhaled drugs and their deposition pattern is briefly addressed. Data show that total lung deposition is a poor predictor of clinical outcome, and that regional deposition needs to be assessed to predict therapeutic effectiveness. Indeed, spatial distribution of deposited particles and, as a consequence, drug efficiency is strongly affected by particle size. Large particles (>6 μm) tend to mainly deposit in the upper airway, limiting the amount of drugs that can be delivered to the lung. Small particles (<2 μm) deposit mainly in the alveolar region and are probably the most apt to act systemically, whereas the particle in the size range 2–6 μm are be best suited to treat the central and small airways.Keywords
This publication has 45 references indexed in Scilit:
- Convective flow dominates aerosol delivery to the lung segmentsJournal of Applied Physiology, 2011
- What the pulmonary specialist should know about the new inhalation therapiesEuropean Respiratory Journal, 2011
- Aerosol Deposition in the Human Lung Periphery Is Increased by Reduced-Density Gas BreathingJournal of Aerosol Medicine and Pulmonary Drug Delivery, 2008
- Deposition and Effects of Inhaled CorticosteroidsClinical Pharmacokinetics, 2003
- Aerosol Bolus Dispersion and Aerosol-Derived Airway Morphometry: Assessment of Lung Pathology and Response to Therapy, Part 1Journal of Aerosol Medicine, 1996
- Detection of early lung impairment with aerosol bolus dispersionEuropean Respiratory Journal, 1994
- Deposition in Man of Particles Inhaled in Air or Helium-Oxygen at Different Flow RatesJournal of Aerosol Medicine, 1990
- Human Lung Deposition of Particles Suspended in Air or in Helium/Oxygen MixtureExperimental Lung Research, 1989
- Effect of methacholine induced bronchoconstriction on the pulmonary distribution and plasma pharmacokinetics of inhaled sodium cromoglycate in subjects with normal and hyperreactive airways.Thorax, 1988
- Behaviour of Airborne Particles in the Respiratory TractPublished by Wiley ,1969