Phenotypic change and accumulation of smooth muscle cells in strictures in Crohn’s disease: relevance to local angiotensin II system
- 2 April 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in The Esophagus
- Vol. 45 (8), 821-830
- https://doi.org/10.1007/s00535-010-0232-6
Abstract
Intestinal stricture lesions in Crohn’s disease are characterized as submucosal fibromuscular accumulation. There has been a controversy about whether the fibrogenic cells in stricture lesions in Crohn’s disease originate from a smooth muscle cell or a fibroblast lineage. In the present study, we aimed to elucidate: (1) the origin of the fibrogenic cells in stricture lesions; and (2) the roles of the local angiotensin II system, including mast cell chymase, in stricture formation.Keywords
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