Habitual intake of flavonoid subclasses and incident hypertension in adults
Top Cited Papers
- 1 February 2011
- journal article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 93 (2), 338-347
- https://doi.org/10.3945/ajcn.110.006783
Abstract
Background: Dietary flavonoids have beneficial effects on blood pressure in intervention settings, but there is limited information on habitual intake and risk of hypertension in population-based studies. Objective: We examined the association between habitual flavonoid intake and incident hypertension in a prospective study in men and women. Design: A total of 87,242 women from the Nurses’ Health Study (NHS) II, 46,672 women from the NHS I, and 23,043 men from the Health Professionals Follow-Up Study (HPFS) participated in the study. Total flavonoid and subclass intakes were calculated from semiquantitative food-frequency questionnaires collected every 4 y by using an updated and extended US Department of Agriculture database. Results: During 14 y of follow-up, 29,018 cases of hypertension in women and 5629 cases of hypertension in men were reported. In pooled multivariate-adjusted analyses, participants in the highest quintile of anthocyanin intake (predominantly from blueberries and strawberries) had an 8% reduction in risk of hypertension [relative risk (RR): 0.92; 95% CI: 0.86, 0.98; P < 0.03] compared with that for participants in the lowest quintile of anthocyanin intake; the risk reduction was 12% (RR: 0.88; 95% CI: 0.84, 0.93; P < 0.001) in participants ≤60 y of age and 0.96 (0.91, 1.02) in participants >60 y of age (P for age interaction = 0.02). Although intakes of other subclasses were not associated with hypertension, pooled analyses for individual compounds suggested a 5% (95% CI: 0.91, 0.99; P = 0.005) reduction in risk for the highest compared with the lowest quintiles of intake of the flavone apigenin. In participants ≤60 y of age, a 6% (95% CI: 0.88, 0.97; P = 0.002) reduction in risk was observed for the flavan-3-ol catechin when the highest and the lowest quintiles were compared. Conclusions: Anthocyanins and some flavone and flavan-3-ol compounds may contribute to the prevention of hypertension. These vasodilatory properties may result from specific structural similarities (including the B-ring hydroxylation and methyoxylation pattern).This publication has 48 references indexed in Scilit:
- Plasma 25-Hydroxyvitamin D Levels and Risk of Incident Hypertension Among Young WomenHypertension, 2008
- (–)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidaseBiochemical and Biophysical Research Communications, 2007
- Dietary Approaches to Prevent and Treat HypertensionHypertension, 2006
- Chocolate Consumption and Incidence of HypertensionHypertension, 2005
- Non-Narcotic Analgesic Dose and Risk of Incident Hypertension in US WomenHypertension, 2005
- Cyanidin‐3‐glucoside regulates phosphorylation of endothelial nitric oxide synthaseFEBS Letters, 2004
- Upregulation of Endothelial Nitric Oxide Synthase by Cyanidin-3-Glucoside, a Typical Anthocyanin PigmentHypertension, 2004
- Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood PressureHypertension, 2003
- Reproducibility and Validity of a Self-Administered Physical Activity QuestionnaireInternational Journal of Epidemiology, 1994
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986