Long‐term reproducibility of positive patch test reactions in patients with non‐immediate cutaneous adverse drug reactions to antibiotics
- 2 December 2016
- journal article
- Published by Wiley in Contact Dermatitis
- Vol. 76 (4), 204-209
- https://doi.org/10.1111/cod.12720
Abstract
As in contact allergy, T cell-mediated hypersensitivity in non-immediate (NI) cutaneous adverse drug reactions (CADRs) to antibiotics is considered to be lifelong, but, in this setting, patch tests have rarely been repeated after long time intervals. To evaluate the long-term reproducibility of positive patch test reactions to antibiotics in patients with NI CADRs. Fifty-six patients with NI CADRs to antibiotics who had relevant positive reactions during patch testing were invited to repeat patch tests with a similar antibiotic series 2–15 years thereafter. Twenty patients were included (9 males and 11 females; mean age 54.6 years): 18 with maculopapular exanthema, 1 with drug hypersensitivity syndrome, and 1 with acute generalized exanthematous pustulosis. Results were reproducible in 17 of 20 patients after a mean interval of 6.0 years (range 2–14.7 years). Concerning β-lactams, 7 of 8 patients remained positive for aminopenicillins, 4 of 4 for isoxazolyl penicillins, and 1 for cefoxitin. Patch test results were also reproducible for clindamycin in 5 of 7 patients, for vancomycin in 1 patient, and for spiramycin in 1 patient. Reproducibility was not affected by the time interval between tests, sex, or age at testing. In the context of NI CADRs, we showed high reproducibility of positive patch test reactions to various antibiotics, even after several years.Keywords
This publication has 19 references indexed in Scilit:
- Patch testing – a valuable tool for investigating non‐immediate cutaneous adverse drug reactions to antibioticsJournal of the European Academy of Dermatology and Venereology, 2016
- European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practiceContact Dermatitis, 2015
- Skin test concentrations for systemically administered drugs – anENDA/EAACIDrug Allergy Interest Group position paperAllergy, 2013
- Recovered Patients with Stevens–Johson Syndrome and Toxic Epidermal Necrolysis Maintain Long-Lived IFN-γ and sFasL Memory ResponsePLOS ONE, 2012
- Value of patch tests in clindamycin-related drug eruptionsContact Dermatitis, 2011
- Drug Allergy: An Updated Practice ParameterAnnals of Allergy, Asthma & Immunology, 2010
- Patch Testing in Non-Immediate Drug EruptionsAllergy, Asthma & Clinical Immunology, 2008
- Course of contact allergy in consecutive eczema patients patch tested with TRUE Test™ panels 1 and 2 at least twice over a 12‐year periodContact Dermatitis, 2005
- Diagnosis of nonimmediate reactions to β‐lactam antibioticsAllergy, 2004
- Patch testing with semisynthetic penicillinsContact Dermatitis, 1987