Results of Medical Research Council Phase II Study of Low Dose Cisplatin and Methotrexate in the Primary Treatment of Locally Advanced (T3 and T4) Transitional Cell Carcinoma of the Bladder
- 1 August 1991
- journal article
- clinical trial
- Published by Wiley in British Journal of Urology
- Vol. 68 (2), 162-168
- https://doi.org/10.1111/j.1464-410x.1991.tb15287.x
Abstract
A series of 49 previously untreated patients with category T3 or T4 bladder cancer underwent treatment with low dose methotrexate and cisplatin; 44 patients were eligible for assessment of response. Complete response (CR) was seen in 5 patients (11%) and partial response in 15 (34%) (overall response rate 45%). Treatment was reasonably well tolerated with no major morbidity and no treatment-related deaths. After a median follow-up of 3.5 years, the 1-year and 2-year survival rates were 70 and 30% respectively. Ten patients remain recurrence-free without having received "definitive local therapy" (cystectomy and/or radiotherapy) at follow-up extending from 20 to 50 months.Keywords
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