Mechanisms of Resistance to Macrolides and Lincosamides: Nature of the Resistance Elements and Their Clinical Implications
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Open Access
- 15 February 2002
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 34 (4), 482-492
- https://doi.org/10.1086/324626
Abstract
Resistance to macrolides and lincosamides is increasingly reported in clinical isolates of gram-positive bacteria. The multiplicity of mechanisms of resistance, which include ribosomal modification, efflux of the antibiotic, and drug inactivation, results in a variety of phenotypes of resistance. There is controversy concerning the clinical relevance of in vitro macrolide resistance. Recent data, however, have shown that eradication of bacteria correlates with clinical outcome of acute otitis media in children and that macrolide therapy results in delayed eradication of macrolide-resistant pneumococci. These results support the need for in vitro detection of macrolide resistance and correct interpretation of susceptibility tests to guide therapy.Keywords
This publication has 70 references indexed in Scilit:
- Serotype 19F Multiresistant Pneumococcal Clone Harboring Two Erythromycin Resistance Determinants [ erm (B) and mef (A)] in South AfricaAntimicrobial Agents and Chemotherapy, 2001
- Identification of an erm (A) Erythromycin Resistance Methylase Gene in Streptococcus pneumoniae Isolated in GreeceAntimicrobial Agents and Chemotherapy, 2001
- Macrolide Resistance Conferred by Base Substitutions in 23S rRNAAntimicrobial Agents and Chemotherapy, 2001
- Induction of Ribosome Methylation in MLS-ResistantStreptococcus pneumoniaeby Macrolides and KetolidesMicrobial Drug Resistance, 1999
- Molecular cloning and functional analysis of a novel macrolide‐resistance determinant, mefA, from Streptococcus pyogenesMolecular Microbiology, 1996
- Insights into erythromycin action from studies of its activity as inducer of resistanceAntimicrobial Agents and Chemotherapy, 1995
- Erythromycin resistance by ribosome modificationAntimicrobial Agents and Chemotherapy, 1995
- Inducible erythromycin resistance in staphlyococci is encoded by a member of the ATP‐binding transport super‐gene familyMolecular Microbiology, 1990
- Clindamycin therapy of staphylococcus aureus endocarditis: Clinical relapse and development of resistance to clindamycin, lincomycin and erythromycinThe American Journal of Medicine, 1976
- THE SENSITIVITY OF STAPHYLOCOCCI AND OTHER WOUND BACTERIA TO ERYTHROMYCIN, OLEANDOMYCIN, AND SPIRAMYCINJournal of Clinical Pathology, 1959