Abstract
Nuclear magnetic resonance (NMR) has been used in basic research by physicists, chemists, and biochemists since its invention in 1946. In the past decade it has been applied in medicine, particularly with the development of magnetic resonance imaging, which produces detailed structural images by measuring the spatial distribution of water. The revolutionary advances made with magnetic resonance imaging have stimulated interest in the use of NMR spectroscopy in vivo to determine the concentrations of metabolites noninvasively and follow changes in their concentrations over time. In both magnetic resonance imaging and NMR spectroscopy, the patient is placed in a large cylindrical . . .