SCY-078, a Novel Fungicidal Agent, Demonstrates Distribution to Tissues Associated with Fungal Infections during Mass Balance Studies with Intravenous and Oral [ 14 C]SCY-078 in Albino and Pigmented Rats

Abstract

SCY-078, a fungicidal ß-1,3-glucan synthesis inhibitor, administered as intravenous or oral [¹⁴C]-SCY-078 to rat, distributed primarily into tissues associated with invasive fungal disease (kidney, lung, liver, spleen, bone marrow, muscle, vaginal tissue, and skin) to levels exceeding plasma. Oral fraction absorbed was ∼40%. Elimination was primarily via bile and feces (∼90%) and urine (∼1.5%). Mean t_1/2 was ∼8 h. Quantitative whole-body autoradiography showed a rapid distribution 8 h post-dose, and elimination by 168 h.