Correlation of in vivo collagen degradation rate with in vitro measurements
- 1 November 1975
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 9 (6), 623-628
- https://doi.org/10.1002/jbm.820090608
Abstract
The rate of in vitro enzymatic degradation of various materials based on collagen has been determined by a novel mechanochemical method, and has been compared with the extent of degradation resulting from subcutaneous implantation in guinea pigs. In vitro data correlate well with in vivo data. It is suggested that the simple in vitro method described is an effective means of screening a large number of materials based on collagen for their ability to resist degradation during implantation in animals.Keywords
This publication has 9 references indexed in Scilit:
- Medical and Surgical Applications of CollagenPublished by Elsevier BV ,1973
- Resistance to collagenase: A characteristic of collagen fibrils cross-linked by formaldehydeBiochimica et Biophysica Acta (BBA) - Protein Structure, 1972
- Studies on the specificity of bacterial collagenaseBiochemical and Biophysical Research Communications, 1970
- Tadpole Collagenase. Preparation and Purification*Biochemistry, 1966
- STUDIES ON COLLAGENPublished by Elsevier BV ,1957
- ISOLATION AND CHARACTERIZATION OF PROTEINASE AND COLLAGENASE FROM CL. HISTOLYTICUM 12JCI Insight, 1953
- Studies concerned with the structure of collagen. II. Stress‐strain behavior of thermally contracted collagenJournal of Polymer Science, 1952
- ESTIMATION OF FORMALDEHYDE IN BIOLOGICAL MIXTURESPublished by Elsevier BV ,1945
- Statistical Mechanics of Cross-Linked Polymer Networks I. Rubberlike ElasticityThe Journal of Chemical Physics, 1943