Soft Matrices Suppress Cooperative Behaviors among Receptor-Ligand Bonds in Cell Adhesion
Open Access
- 23 August 2010
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 5 (8), e12342
- https://doi.org/10.1371/journal.pone.0012342
Abstract
The fact that biological tissues are stable over prolonged periods of time while individual receptor-ligand bonds only have limited lifetime underscores the critical importance of cooperative behaviors of multiple molecular bonds, in particular the competition between the rate of rupture of closed bonds (death rate) and the rate of rebinding of open bonds (birth rate) in a bond cluster. We have recently shown that soft matrices can greatly increase the death rate in a bond cluster by inducing severe stress concentration near the adhesion edges. In the present paper, we report a more striking effect that, irrespective of stress concentration, soft matrices also suppress the birth rate in a bond cluster by increasing the local separation distance between open bonds. This is shown by theoretical analysis as well as Monte Carlo simulations based on a stochastic-elasticity model in which stochastic descriptions of molecular bonds and elastic descriptions of interfacial force/separation are unified in a single modeling framework. Our findings not only are important for understanding the role of elastic matrices in cell adhesion, but also have general implications on adhesion between soft materials.This publication has 55 references indexed in Scilit:
- A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cellsProceedings of the National Academy of Sciences of the United States of America, 2010
- Lifetime and Strength of Periodic Bond Clusters between Elastic Media under Inclined LoadingBiophysical Journal, 2009
- Characterizing the resistance generated by a molecular bond as it is forcibly separatedProceedings of the National Academy of Sciences of the United States of America, 2009
- Bistability of Cell-Matrix Adhesions Resulting from Nonlinear Receptor-Ligand DynamicsBiophysical Journal, 2006
- Local force and geometry sensing regulate cell functionsNature Reviews Molecular Cell Biology, 2006
- Stochastic dynamics of adhesion clusters under shared constant force and with rebindingThe Journal of Chemical Physics, 2004
- Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblastsThe Journal of cell biology, 2004
- Synaptic pattern formation during cellular recognitionProceedings of the National Academy of Sciences of the United States of America, 2001
- Contact MechanicsJournal of Tribology, 1986
- Exact stochastic simulation of coupled chemical reactionsThe Journal of Physical Chemistry, 1977