Anti-N-homocysteinylated protein autoantibodies and cardiovascular disease
- 1 January 2005
- journal article
- review article
- Published by Walter de Gruyter GmbH in cclm
- Vol. 43 (10), 1011-4
- https://doi.org/10.1515/cclm.2005.177
Abstract
Metabolic conversion of homocysteine (Hcy) to a chemically reactive metabolite, Hcy-thiolactone, catalyzed by methionyl-tRNA synthetase is the first step in a pathway that is suggested to contribute to Hcy toxicity in humans. The accumulation of Hcy-thiolactone is detrimental because of its intrinsic ability to modify proteins by formingKeywords
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