Regulation of neuronal communication by G protein‐coupled receptors
- 13 May 2015
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 589 (14), 1607-1619
- https://doi.org/10.1016/j.febslet.2015.05.007
Abstract
Neuronal communication plays an essential role in the propagation of information in the brain and requires a precisely orchestrated connectivity between neurons. Synaptic transmission is the mechanism through which neurons communicate with each other. It is a strictly regulated process which involves membrane depolarization, the cellular exocytosis machinery, neurotransmitter release from synaptic vesicles into the synaptic cleft, and the interaction between ion channels, G protein-coupled receptors (GPCRs), and downstream effector molecules. The focus of this review is to explore the role of GPCRs and G protein-signaling in neurotransmission, to highlight the function of GPCRs, which are localized in both presynaptic and postsynaptic membrane terminals, in regulation of intrasynaptic and intersynaptic communication, and to discuss the involvement of astrocytic GPCRs in the regulation of neuronal communication. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.Keywords
This publication has 203 references indexed in Scilit:
- A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytesPurinergic Signalling, 2013
- Modulation of firing and synaptic transmission of serotonergic neurons by intrinsic G protein-coupled receptors and ion channelsFrontiers in Integrative Neuroscience, 2013
- NPY and Stress 30 Years Later: The Peripheral ViewCellular and Molecular Neurobiology, 2012
- 5-HT1A receptor-regulated signal transduction pathways in brainCellular Signalling, 2010
- Adrenoceptors in brain: Cellular gene expression and effects on astrocytic metabolism and [Ca2+]iNeurochemistry International, 2010
- Cannabinoid and cannabinoid‐like receptors in microglia, astrocytes, and astrocytomasGlia, 2010
- TRPC3 Channels Are Required for Synaptic Transmission and Motor CoordinationNeuron, 2008
- CB1 receptor-dependent and -independent inhibition of excitatory postsynaptic currents in the hippocampus by WIN 55,212-2Neuropharmacology, 2008
- Mechanisms of glutamate release from astrocytesNeurochemistry International, 2007
- STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ InfluxCurrent Biology, 2005