Serum Clara cell protein (CC16) in healthy young smokers
- 1 January 2000
- journal article
- Published by Informa UK Limited in Biomarkers
- Vol. 5 (2), 158-164
- https://doi.org/10.1080/135475000230479
Abstract
The CC16 microprotein is the main secretory product of Clara cells, which are epithelial cells lining lung airways. In crossing through the bronchoalveolar/blood barrier, CC16 diffuses passively into plasma. Serum CC16 (sCC16) has recently been proposed as a biomarker for detecting Clara cell impairments. The aim of this study was to assess if sCC16 concentrations are reduced in a group of healthy young smokers. A group of 118 healthy young males volunteered to take part in the study. Each subject answered a questionnaire, and provided blood and urine samples. Serum CC16, urinary cotinine and creatinine were measured. Median serum CC16 concentrations were lower in smokers than in non-smokers (11.3 mug l(-1) vs 14.6 mug l(-1); p = 0.005; N = 89 and 29, respectively) but did not correlate with either the daily or the life-time cigarette consumption, or with urinary cotinine concentrations. sCC16 did not correlate with age or body mass index in the whole study population or in the groups of smokers and non-smokers. These results suggest the reduction in sCC16 concentrations in a group of healthy young smokers may be an early effect of cigarette smokingKeywords
This publication has 19 references indexed in Scilit:
- Lung Epithelium–specific ProteinsAmerican Journal of Respiratory and Critical Care Medicine, 1999
- Clara Cell Protein Correlation With HyperlipidemiaChest, 1996
- Clara cell protein (CC16): characteristics and potential applications as biomarker of lung toxicityBiomarkers, 1996
- Potent inhibition of both human interferon-gamma production and biologic activity by the Clara cell protein CC16.American Journal of Respiratory Cell and Molecular Biology, 1995
- Serum Clara Cell Protein: An Indicator of Bronchial Cell Dysfunction Caused by Tobacco SmokingEnvironmental Research, 1994
- The validity of self-reported smoking: a review and meta-analysis.American Journal of Public Health, 1994
- The molecular mass and concentrations of protein 1 or Clara cell protein in biological fluids: A reappraisalClinica Chimica Acta; International Journal of Clinical Chemistry, 1993
- A rapid gas-liquid chromatographic method for the determination of cotinine and nicotine in biological fluidsJournal of Pharmacy and Pharmacology, 1990
- Uteroglobin: Structure, Molecular Biology, and New Perspectives on Its Function as a Phospholipase A2InhibitorEndocrine Reviews, 1987
- An immunologic study of the secretory products of rat Clara cells.Journal of Histochemistry & Cytochemistry, 1984