Heart failure with preserved ejection fraction in Asia
- 16 August 2018
- journal article
- research article
- Published by Wiley in European Journal of Heart Failure
- Vol. 21 (1), 23-36
- https://doi.org/10.1002/ejhf.1227
Abstract
Background Heart failure with preserved ejection fraction (HFpEF) is a global public health problem. Unfortunately, little is known about HFpEF across Asia. Methods and results We prospectively studied clinical characteristics, echocardiographic parameters and outcomes in 1204 patients with HFpEF (left ventricular ejection fraction ≥50%) from 11 Asian regions, grouped as Northeast Asia (Hong Kong, Taiwan, China, Japan, Korea, n = 543), South Asia (India, n = 252), and Southeast Asia (Malaysia, Thailand, Singapore, Indonesia, Philippines, n = 409). Mean age was 68 ±12 years (37% were < 65 years) and 50% were women. Seventy per cent of patients had ≥2 co‐morbidities, most commonly hypertension (71%), followed by anaemia (57%), chronic kidney disease (50%), diabetes (45%), coronary artery disease (29%), atrial fibrillation (29%) and obesity (26%). Southeast Asian patients had the highest prevalence of all co‐morbidities except atrial fibrillation, South Asians had the lowest prevalence of all co‐morbidities except anaemia and obesity, and Northeast Asians had more atrial fibrillation. Left ventricular hypertrophy and concentric remodelling were most prominent among Southeast and South Asians, respectively (P < 0.001). Overall, 12.1% of patients died or were hospitalized for heart failure within 1 year. Southeast Asians were at higher risk for adverse outcomes, independent of co‐morbidity burden and cardiac geometry. Conclusion These first prospective multinational data from Asia show that HFpEF affects relatively young patients with a high burden of co‐morbidities. Regional differences in types of co‐morbidities, cardiac remodelling and outcomes of HFpEF across Asia have important implications for public health measures and global HFpEF trial design.Keywords
Funding Information
- Bayer
This publication has 47 references indexed in Scilit:
- Clinical Features and Outcome in Hospitalized Heart Failure in Japan (From the ATTEND Registry)Circulation Journal, 2013
- ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012European Journal of Heart Failure, 2012
- Trends in Patients Hospitalized With Heart Failure and Preserved Left Ventricular Ejection FractionCirculation, 2012
- Aliskiren, ALTITUDE, and the implications for ATMOSPHEREEuropean Journal of Heart Failure, 2012
- Body Mass Index and Adverse Cardiovascular Outcomes in Heart Failure Patients With Preserved Ejection FractionCirculation: Heart Failure, 2011
- Trend of Westernization of Etiology and Clinical Characteristics of Heart Failure Patients in JapanCirculation Journal, 2011
- Clinical features of heart failure hospitalization in younger and elderly patients in TaiwanEuropean Journal of Clinical Investigation, 2010
- Cardiac Structure and Ventricular–Vascular Function in Persons With Heart Failure and Preserved Ejection Fraction From Olmsted County, MinnesotaCirculation, 2007
- Analysis of Chronic Heart Failure Registry in the Tohoku District-Third Year Follow-up-Circulation Journal, 2004
- The EuroHeart Failure survey programme—a survey on the quality of care among patients with heart failure in Europe Part 1: patient characteristics and diagnosisEuropean Heart Journal, 2003