Aspirin, Heparin, and Fibrinolytic Therapy in Suspected Acute Myocardial Infarction

Abstract

In this article, we review the randomized clinical trials of aspirin, of heparin, and of fibrinolytic therapy in patients with suspected acute myocardial infarction to determine which of these treatments have been shown to improve survival and other major clinical outcomes.AspirinBenefits of Aspirin during and after Suspected Myocardial InfarctionThe Second International Study of Infarct Survival (ISIS-2) demonstrated conclusively the substantial value of aspirin therapy in patients with suspected acute myocardial infarction¹ (and other studies have shown the value of aspirin in patients with unstable angina²). In the ISIS-2 trial, assignment to one month of treatment with . . .