Gene Variants of VAMP8 and HNRPUL1 Are Associated With Early-Onset Myocardial Infarction
- 1 July 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 26 (7), 1613-1618
- https://doi.org/10.1161/01.atv.0000226543.77214.e4
Abstract
Objectives— Identify gene variants associated with early-onset myocardial infarction (MI). Methods and Results— We tested 11 647 single-nucleotide polymorphisms (SNPs) for association with early-onset MI in a case-control study (study 1 200 cases, 262 controls). To reduce the number of false positives among the 666 SNPs that were nominally associated with early-onset MI ( P P P =0.025; odds ratio [OR], 1.75; CI, 1.17 to 2.62) and an HNRPUL1 variant ( P =0.0043; OR, 1.92; CI, 1.28 to 2.86) were associated with early-onset MI (nominal P Conclusions— Variants in 2 genes were associated with early-onset MI: VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein. The identification of these variants could improve understanding of disease mechanisms and suggest novel drug targets.Keywords
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