Prevention of Acute Graft Rejection by the Prostaglandin E1Analogue Misoprostol in Renal-Transplant Recipients Treated with Cyclosporine and Prednisone

Abstract

Prostaglandins of the E series have been shown to have immunosuppressive properties. To study the effects of the prostaglandin E₁ analogue misoprostol on renal function and graft rejection after transplantation, we conducted a randomized, double-blind, placebo-controlled trial in 77 renal-allograft recipients.